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Workflow will not run on certain machines


Our organization has recently upgraded to SharePoint 2010. The custom workflow activities was installed successfully. However, workflows contain any of those custom workflow activities will not run on some machines. I happened to be one of unfortunate ones that cannot run those workflows. When I exam the workflow from my machine, I would see an error message "Could not deserialize object.." in place of the custom activities. But when I exam the same workflow from another machine, it would appear to be just fine.
We tried rebuilt my machine, deleted caches and nothing seems to work.
Has anyone encountered a similar problem and could offer a possible solution?