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Workflow will not run on certain machines

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Our organization has recently upgraded to SharePoint 2010. The custom workflow activities was installed successfully. However, workflows contain any of those custom workflow activities will not run on some machines. I happened to be one of unfortunate ones that cannot run those workflows. When I exam the workflow from my machine, I would see an error message "Could not deserialize object.." in place of the custom activities. But when I exam the same workflow from another machine, it would appear to be just fine.
We tried rebuilt my machine, deleted caches and nothing seems to work.
Has anyone encountered a similar problem and could offer a possible solution?
Thanks.

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